QuickView for ciliary neurotrophic factor;jsessionid=E11B80A8EDAB8A00C9C321E5724A24F0;jsessionid=662F29C895ADFE0672DB4D2168F1B7A3;jsessionid=87EAC27529F36ABD14AF8760BAAA39C5;jsessionid=CB8EEB0EE9F8BB35E860FB9A43B8540F (gene)
- Gene Symbol:
- Cntf
Mus musculus - Full name:
- ciliary neurotrophic factor
- Synonyms:
- AI429687, ciliary neurotrophic factor
- Genomic Location:
- Chr 19: 12838018-12840122
- Description:
-
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes, and it may be involved in reducing tissue destruction duri...
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Gallus gallus , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
protein-containing complex binding | signaling receptor binding | cytokine receptor binding | molecular function regulator | ciliary neurotrophic factor receptor binding | protein binding | receptor regulator activity | growth factor activity | receptor ligand activity | cytokine activity | growth factor receptor binding | interleukin-6 receptor binding
GO Biological Process
response to cytokine | positive regulation of cellular component organization | regulation of cell morphogenesis | regulation of neurogenesis | intracellular signal transduction | positive regulation of axon regeneration | regulation of cell development | regulation of localization | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | astrocyte development | negative regulation of neuron death | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | JAK-STAT cascade | nervous system development | positive regulation of axonogenesis | neurogenesis | positive regulation of phosphate metabolic process | generation of neurons | regulation of neuron death | ciliary neurotrophic factor-mediated signaling pathway | cellular process | neuron development | negative regulation of apoptotic process | regulation of tyrosine phosphorylation of STAT protein | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | regulation of resting membrane potential | regulation of cell differentiation | muscle structure development | regulation of cellular process | positive regulation of cell growth | regulation of apoptotic process | regulation of metabolic process | gliogenesis | positive regulation of cellular protein metabolic process | cellular component organization | negative regulation of photoreceptor cell differentiation | muscle organ morphogenesis | response to stimulus | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | positive regulation of phosphatidylinositol 3-kinase signaling | positive regulation of JAK-STAT cascade | regulation of cell proliferation | regulation of neuron projection regeneration | positive regulation of hormone secretion | regulation of cellular component size | cellular component assembly | regulation of axon extension | molecular function regulator | regulation of membrane potential | regulation of cellular response to stress | negative regulation of neuron apoptotic process | system development | positive regulation of response to wounding | regulation of signal transduction | positive regulation of neuron projection development | astrocyte activation | multicellular organism development | regulation of MAPK cascade | regulation of axonogenesis | membrane hyperpolarization | protein complex oligomerization | regulation of phosphorylation | regulation of hormone levels | positive regulation of neuron projection regeneration | regulation of hormone secretion | regulation of neuron differentiation | regulation of gene expression | regulation of retinal cell programmed cell death | positive regulation of secretion | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | animal organ morphogenesis | regulation of nitrogen compound metabolic process | positive regulation of cell projection organization | positive regulation of STAT cascade | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | positive regulation of cell differentiation | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | glial cell differentiation | cell communication | regulation of cellular metabolic process | regulation of neuron apoptotic process | positive regulation of tyrosine phosphorylation of STAT protein | astrocyte differentiation | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of cell proliferation | regulation of protein phosphorylation | positive regulation of transport | positive regulation of axon extension involved in regeneration | positive regulation of axon extension | neuron differentiation | regulation of signaling receptor activity | receptor regulator activity | protein-containing complex assembly | regulation of cell morphogenesis involved in differentiation | positive regulation of protein modification process | regulation of growth | response to organic substance | regulation of photoreceptor cell differentiation | regulation of JAK-STAT cascade | regulation of animal organ morphogenesis | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | positive regulation of neurogenesis | growth factor activity | positive regulation of cell development | negative regulation of programmed cell death | regulation of secretion | receptor ligand activity | cytokine activity | animal organ development | negative regulation of neuron differentiation | regulation of phosphate metabolic process | cell activation | positive regulation of MAPK cascade | regulation of axon regeneration | regulation of response to wounding | regulation of cell communication | positive regulation of developmental growth | signaling | positive regulation of growth | glial cell development | cell development | regulation of developmental growth | positive regulation of phosphorylation | regulation of cell size | protein heterooligomerization | anatomical structure morphogenesis | regulation of nervous system development | regulation of developmental process | developmental process | regulation of cell growth | regulation of transport | central nervous system development | positive regulation of metabolic process | positive regulation of neuron differentiation | regulation of cell projection organization | cellular response to organic substance | regulation of cell death | positive regulation of cell morphogenesis involved in differentiation | negative regulation of cell death | negative regulation of cell development | negative regulation of cell differentiation | regulation of cellular component organization | muscle organ development | positive regulation of signaling | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | positive regulation of gene expression | negative regulation of neurogenesis | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | neuron projection | somatodendritic compartment | cell body | cell | neuronal cell body | cytoplasm | intracellular organelle | cell projection | plasma membrane bounded cell projection cytoplasm | cytoplasmic region | extracellular region | membrane-bounded organelle | nucleus | organelle | extracellular space | axon | cytosol | intracellular
